| http://purl.uniprot.org/citations/12853475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12853475 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wiskott-Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin-cytoskeletal reorganization downstream of the small Rho GTPase, Rac. We inactivated the WAVE2 gene by gene-targeted mutation to examine its role in murine development and in actin assembly. WAVE2-deficient embryos survived until approximately embryonic day 12.5 and displayed growth retardation and certain morphological defects, including malformations of the ventricles in the developing brain. WAVE2-deficient embryonic stem cells displayed normal proliferation, whereas WAVE2-deficient embryonic fibroblasts exhibited severe growth defects, as well as defective cell motility in response to PDGF, lamellipodium formation and Rac-mediated actin polymerization. These results imply a non-redundant role for WAVE2 in murine embryogenesis and a critical role for WAVE2 in actin-based processes downstream of Rac that are essential for cell movement."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg350"xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Snapper S.B."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Bronson R."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Shinkura R."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Rosen F.S."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Martinez-Quiles N."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Geha R."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Eden S."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/author | "Takeshima F."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/pages | "3602-3612"xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/title | "WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility."xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12853475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12853475 |
| http://purl.uniprot.org/citations/12853475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12853475 |
| http://purl.uniprot.org/uniprot/P63001#attribution-13681C3C45A4BD6AFC8F64E8C5E93E63 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12853475 |
| http://purl.uniprot.org/uniprot/Q8BH43#attribution-8A2CEB953210F6BE3CBE7BD14E813D95 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12853475 |