| http://purl.uniprot.org/citations/12855574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12855574 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by immune dysfunction, thrombocytopenia, and eczema. We used a murine model created by knockout of the WAS protein gene (WASP) to evaluate the potential of gene therapy for WAS. Lethally irradiated, male WASP-animals that received transplants of mixtures of wild type (WT) and WASP-bone marrow cells demonstrated enrichment of WT cells in the lymphoid and myeloid lineages with a progressive increase in the proportion of WT T-lymphoid and B-lymphoid cells. WASP-mice had a defective secondary T-cell response to influenza virus which was normalized in animals that received transplants of 35% or more WT cells. The WASP gene was inserted into WASP-bone marrow cells with a bicistronic oncoretroviral vector also encoding green fluorescent protein (GFP), followed by transplantation into irradiated male WASP-recipients. There was a selective advantage for gene-corrected cells in multiple lineages. Animals with higher proportions of GFP+ T cells showed normalization of their lymphocyte counts. Gene-corrected, blood T cells exhibited full and partial correction, respectively, of their defective proliferative and cytokine secretory responses to in vitro T-cell-receptor stimulation. The defective secondary T-cell response to influenza virus was also improved in gene-corrected animals."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-11-3489"xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Srivastava D.K."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Cunningham J.M."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Turner S.J."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Doherty P.C."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Nienhuis A.W."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Andreansky S."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/author | "Strom T.S."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/pages | "3108-3116"xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/title | "Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells."xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/12855574 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12855574 |
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| http://purl.uniprot.org/uniprot/#_P70315-mappedCitation-12855574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12855574 |
| http://purl.uniprot.org/uniprot/#_Q61078-mappedCitation-12855574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12855574 |
| http://purl.uniprot.org/uniprot/Q61078 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12855574 |
| http://purl.uniprot.org/uniprot/P70315 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12855574 |
| http://purl.uniprot.org/uniprot/Q53WY0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12855574 |