| http://purl.uniprot.org/citations/12855590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12855590 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) within the MS7 sequence. We now report that MS7 contains a C/EBP-binding site (C/EBP-100), which overlaps with AML-110 and is bound by C/EBP factors in myeloid cells. C/EBP and RUNX/AML factors compete for binding to their respective cognate elements and bind to the CD11a promoter MS7 sequence in a cell lineage- and differentiation-dependent manner. In myeloid cells MS7 is primarily recognized by C/EBP factors in proliferating cells whereas RUNX/AML factors (especially RUNX3/AML-2) bind to MS7 in differentiated cells. RUNX3/AML-2 binding to the CD11a promoter correlates with increased RUNX3/AML-2 protein levels and enhanced CD11a/CD18 cell surface expression. The relevance of the AML-110 element is underscored by the ability of AML-1/ETO to inhibit CD11a promoter activity, thus explaining the low CD11a/CD18 expression in t(8;21)-containing myeloid leukemia cells. Therefore, the expression of the CD11a/CD18 integrin in myeloid cells is determined through the differential occupancy of the CD11a proximal promoter by transcription factors implicated in the pathogenesis of myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-02-0618"xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Groner Y."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Ruiz N."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Sanchez-Elsner T."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Drabkin H."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Corbi A.L."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Gil J."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Puig-Kroger A."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Jensen U.B."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Prosper F."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Erickson P."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/author | "Andreu E.J."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/pages | "3252-3261"xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/title | "RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements."xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/12855590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12855590 |
| http://purl.uniprot.org/citations/12855590 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12855590 |
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| http://purl.uniprot.org/uniprot/#_B2RAL6-mappedCitation-12855590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12855590 |
| http://purl.uniprot.org/uniprot/#_B4DQ77-mappedCitation-12855590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12855590 |
| http://purl.uniprot.org/uniprot/#_B4E021-mappedCitation-12855590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12855590 |