| http://purl.uniprot.org/citations/12858167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12858167 | http://www.w3.org/2000/01/rdf-schema#comment | "High plasma levels of soluble P-selectin are associated with thrombotic disorders and may predict future cardiovascular events. Mice with high levels of soluble P-selectin have more microparticles in their plasma than do normal mice. Here we show that chimeras of P-selectin and immunoglobulin (P-sel-Ig) induced formation of procoagulant microparticles in human blood through P-selectin glycoprotein ligand-1 (PSGL-1; encoded by the Psgl1 gene, officially known as Selpl). In addition, Psgl1-/-mice produced fewer microparticles after P-sel-Ig infusion and did not spontaneously increase their microparticle count in old age as do wild-type mice. Injected microparticles specifically bound to thrombi and thus could be involved in thrombin generation at sites of injury. Infusion of P-sel-Ig into hemophilia A mice produced a 20-fold increase over control immunoglobulin in microparticles containing tissue factor. This significantly improved the kinetics of fibrin formation in the hemophilia A mice and normalized their tail-bleeding time. P-sel-Ig treatment could become a new approach to sustained control of bleeding in hemophilia."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm899"xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Widom A."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Wagner D.D."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "McEver R.P."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Hrachovinova I."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Kazazian H.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Camphausen R.T."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Hafezi-Moghadam A."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Schaub R.G."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Cambien B."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/author | "Kappelmayer J."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/pages | "1020-1025"xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/title | "Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A."xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/12858167 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12858167 |
| http://purl.uniprot.org/citations/12858167 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12858167 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTY7-mappedCitation-12858167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858167 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUH7-mappedCitation-12858167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858167 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z509-mappedCitation-12858167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858167 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV23-mappedCitation-12858167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858167 |