| http://purl.uniprot.org/citations/12858454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12858454 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo examine association of 8 candidate genes with susceptibility to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japanese patients. Little is known on the genetic background of AAV in Japanese patients mainly because of the difficulty in collecting a sufficient number of samples for the genetics study.MethodsSixty-nine patients, including 50 with microscopic polyangiitis (MPA), were recruited in a multicenter study. Among them, 64 patients were positive for myeloperoxidase (MPO)-ANCA. Associations of HLA-DRB1, tumor necrosis factor-alpha promoter (TNF), TNF receptor 2 (TNFR2), Fcgamma receptor IIa (FCGR2A), IIb (FCGR2B), IIIa (FCGR3A), IIIb (FCGR3B), and CTLA-4 (CTLA4) polymorphisms were examined in a case-control analysis.ResultsA significant association of HLA-DRB1*0901 with MPA (p = 0.0037, OR 2.44, 95% CI 1.33-4.46), as well as with MPO-ANCA positivity (p = 0.0014, OR 2.44, 95% CI 1.41-4.22), was detected. There was no difference in the TNF promoter haplotype frequencies between patients with MPA and controls, excluding the possibility that the association of DRB1*0901 was secondarily caused by linkage disequilibrium with TNF. No association was observed for TNFR2, FCGR, or CTLA4 with MPA, nor with the presence of MPO-ANCA, although the combined genotype FCGR2A-131H/H and 3A-176F/F was increased in patients with MPA (p = 0.025).ConclusionThere was an association of HLA-DRB1*0901 with MPA and MPO-ANCA positive vasculitis in Japanese patients."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Hashimoto H."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Tokunaga K."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Arimura Y."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Tsuchiya N."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Kyogoku C."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/author | "Kawasaki A."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/name | "J Rheumatol"xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/pages | "1534-1540"xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/title | "Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis."xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/12858454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12858454 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12858454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858454 |
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| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-12858454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12858454 |
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