| http://purl.uniprot.org/citations/12859895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12859895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12859895 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of infectious virions by CD4(+) lymphocytes. Vif facilitates particle infectivity by blocking the inhibitory activity of APOBEC3G (CEM15), a virion-encapsidated cellular protein that deaminates minus-strand reverse transcript cytosines to uracils. We report that HIV-1 Vif forms a complex with human APOBEC3G that prevents its virion encapsidation. HIV-1 Vif did not efficiently form a complex with mouse APOBEC3G. Vif dramatically reduced the amount of human APOBEC3G encapsidated in HIV-1 virions but did not prevent encapsidation of mouse or AGM APOBEC3G. As a result, these enzymes are potent inhibitors of wild-type HIV-1 replication. The species-specificity of this interaction may play a role in restricting HIV-1 infection to humans. Together these findings suggest that therapeutic intervention that either induced APOBEC3G or blocked its interaction with Vif could be clinically beneficial."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00515-4"xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00515-4"xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Muenk C."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Muenk C."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Bollman B."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Bollman B."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Koenig R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Koenig R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Landau N.R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Landau N.R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Mariani R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Mariani R."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Navarro F."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Navarro F."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Nymark-McMahon H."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Nymark-McMahon H."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Schroefelbauer B."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/author | "Schroefelbauer B."xsd:string |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12859895 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |