| http://purl.uniprot.org/citations/12861002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12861002 | http://www.w3.org/2000/01/rdf-schema#comment | "In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is primarily restricted to slow type I fibers; however, its expression can be induced in fast type II fibers in response to a sustained increase in load-bearing work (mechanical overload [MOV]). Our previous betaMyHC transgenic and protein-DNA interaction studies have identified an A/T-rich element (betaA/T-rich -269/-258) that is required for slow muscle expression and which potentiates MOV responsiveness of a 293-bp betaMyHC promoter (beta293wt). Despite the GATA/MEF2-like homology of this element, we found binding of two unknown proteins that were antigenically distinct from GATA and MEF2 isoforms. By using the betaA/T-rich element as bait in a yeast one-hybrid screen of an MOV-plantaris cDNA library, we identified nominal transcription enhancer factor 1 (NTEF-1) as the specific betaA/T-rich binding factor. Electrophoretic mobility shift assay analysis confirmed that NTEF-1 represents the enriched binding activity obtained only when the betaA/T-rich element is reacted with MOV-plantaris nuclear extract. Moreover, we show that TEF proteins bind MEF2 elements located in the control region of a select set of muscle genes. In transient-coexpression assays using mouse C2C12 myotubes, TEF proteins transcriptionally activated a 293-bp betaMyHC promoter devoid of any muscle CAT (MCAT) sites, as well as a minimal thymidine kinase promoter-luciferase reporter gene driven by three tandem copies of the desmin MEF2 or palindromic Mt elements or four tandem betaA/T-rich elements. These novel findings suggest that in addition to exerting a regulatory effect by binding MCAT elements, TEF proteins likely contribute to regulation of skeletal, cardiac, and smooth muscle gene networks by binding select A/T-rich and MEF2 elements under basal and hypertrophic conditions."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.15.5143-5164.2003"xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Ji J."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Mao X."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Zhang A."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Karasseva N."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Tsika G."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/author | "Tsika R."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/pages | "5143-5164"xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/title | "Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions."xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12861002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12861002 |
| http://purl.uniprot.org/citations/12861002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12861002 |
| http://purl.uniprot.org/uniprot/#_A6I870-mappedCitation-12861002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12861002 |
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| http://purl.uniprot.org/uniprot/#_P30051-mappedCitation-12861002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12861002 |
| http://purl.uniprot.org/uniprot/#_Q3USK5-mappedCitation-12861002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12861002 |