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| http://purl.uniprot.org/citations/12861022 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned T-cell factor 4N (TCF-4N), an alternative isoform of TCF-4, from developing pituitary and 3T3-L1 preadipocytes. This protein contains the N-terminal interaction domain for beta-catenin but lacks the DNA binding domain. While TCF-4N inhibited coactivation by beta-catenin of a TCF/lymphoid-enhancing factor (LEF)-dependent promoter, TCF-4N potentiated coactivation by beta-catenin of several non-TCF/LEF-dependent promoters. For example, TCF-4N synergized with beta-catenin to activate the alpha-inhibin promoter through functional and physical interactions with the orphan nuclear receptor steroidogenic factor 1 (SF-1). In addition, TCF-4N and beta-catenin synergized with the adipogenic transcription factor CCAAT/enhancer binding protein alpha (C/EBPalpha) to induce leptin promoter activity. The mechanism by which beta-catenin and TCF-4N coactivated C/EBPalpha appeared to involve p300, based upon synergy between these important transcriptional regulators. Consistent with TCF-4N's redirecting the actions of beta-catenin in cells, ectopic expression of TCF-4N in 3T3-L1 preadipocytes partially relieved the block of adipogenesis caused by beta-catenin. Thus, we propose that TCF-4N inhibits coactivation by beta-catenin of TCF/LEF transcription factors and potentiates the coactivation by beta-catenin of other transcription factors, such as SF-1 and C/EBPalpha."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.15.5366-5375.2003"xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/author | "Hammer G.D."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/author | "MacDougald O.A."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/author | "O'Leary E.E."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/author | "Kennell J.A."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/author | "Gummow B.M."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/pages | "5366-5375"xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/title | "T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors."xsd:string |
| http://purl.uniprot.org/citations/12861022 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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