| http://purl.uniprot.org/citations/12864861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12864861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12864861 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA microarray covering the whole genome of Staphylococcus aureus strain N315 was prepared to investigate transcription profiles. The microarray analyses revealed that vancomycin induces transcription of 139 genes. Forty-six genes among them failed to be induced in the vraSR null mutant KVR. Part of the genes regulated by VraSR system is associated with cell-wall biosynthesis, such as PBP2, SgtB and MurZ. Other cell-wall synthesis inhibitors also induced VraSR, suggesting that the sensor kinase VraS responds to the damage of cell-wall structure or inhibition of cell-wall biosynthesis. Additionally, the vraSR null mutants derived from hetero- and homo-methicillin-resistant S. aureus showed significant decrease of resistance against teicoplanin, beta-lactam, bacitracin and fosfomycin but not of D-cycloserine and levofloxacin. The observation strongly indicates that VraSR constitutes a positive regulator of cell-wall peptidoglycan synthesis, and that is deeply involved in the expression of beta-lactam and glycopeptide resistance in S. aureus."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.2003.03599.x"xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.2003.03599.x"xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Kuroda H."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Kuroda H."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Hiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Hiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Oshima T."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Oshima T."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Takeuchi F."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/author | "Takeuchi F."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/pages | "807-821"xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/pages | "807-821"xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/title | "Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus."xsd:string |
| http://purl.uniprot.org/citations/12864861 | http://purl.uniprot.org/core/title | "Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus."xsd:string |