| http://purl.uniprot.org/citations/12865332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12865332 | http://www.w3.org/2000/01/rdf-schema#comment | "Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2alpha kinase) show severe postnatal growth retardation. In mice, growth retardation in Perk-/-mutants is manifested within the first few days of neonatal development. Growth parameters of Perk-/-mice, including comparison of body weight to length and organ weights, are consistent with proportional dwarfism. Tibia growth plates exhibited a reduction in proliferative and hypertrophic chondrocytes underlying the longitudinal growth retardation. Neonatal Perk-/-deficient mice show a 75% reduction in liver IGF-I mRNA and serum IGF-I within the first week, whereas the expression of IGF-I mRNA in most other tissues is normal. Injections of IGF-I partially reversed the growth retardation of the Perk-/-mice, whereas GH had no effect. Transgenic rescue of PERK activity in the insulin- secreting beta-cells of the Perk-/-mice reversed the juvenile but not the neonatal growth retardation. We provide evidence that circulating IGF-I is derived from neonatal liver but is independent of GH at this stage. We propose that PERK is required to regulate the expression of IGF-I in the liver during the neonatal period, when IGF-I expression is GH-independent, and that the lack of this regulation results in severe neonatal growth retardation."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2003-0236"xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Iida K."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "O'Neil J."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Cavener D.R."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Frank A."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Rosen C.J."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Liang S.H."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Zambito F."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/author | "Gabai A."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/pages | "3505-3513"xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/title | "PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver."xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://purl.uniprot.org/core/volume | "144"xsd:string |
| http://purl.uniprot.org/citations/12865332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12865332 |
| http://purl.uniprot.org/citations/12865332 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12865332 |
| http://purl.uniprot.org/uniprot/Q9Z2B5#attribution-016F9EDF6BFC1FE9FABDA30EFE4A9820 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12865332 |
| http://purl.uniprot.org/uniprot/P05017#attribution-64980A24B72ED553D73F2D17497D4AE3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12865332 |
| http://purl.uniprot.org/uniprot/#_D3Z7M4-mappedCitation-12865332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12865332 |
| http://purl.uniprot.org/uniprot/#_E9PU89-mappedCitation-12865332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12865332 |