| http://purl.uniprot.org/citations/12865419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12865419 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte nuclear factors-3 (Foxa-1-3) are winged forkhead transcription factors that regulate gene expression in the liver and pancreatic islets and are required for normal metabolism. Here we show that Foxa-2 is expressed in preadipocytes and induced de novo in adipocytes of genetic and diet-induced rodent models of obesity. In preadipocytes Foxa-2 inhibits adipocyte differentiation by activating transcription of the Pref-1 gene. Foxa-2 and Pref-1 expression can be enhanced in primary preadipocytes by growth hormone, suggesting that the antiadipogenic activity of growth hormone is mediated by Foxa-2. In differentiated adipocytes Foxa-2 expression leads to induction of gene expression involved in glucose and fat metabolism, including glucose transporter-4, hexokinase-2, muscle-pyruvate kinase, hormone-sensitive lipase, and uncoupling proteins-2 and -3. Diet-induced obese mice with haploinsufficiency in Foxa-2 (Foxa-2+/-) develop increased adiposity compared with wild-type littermates as a result of decreased energy expenditure. Furthermore, adipocytes of these Foxa-2+/-mice exhibit defects in glucose uptake and metabolism. These data suggest that Foxa-2 plays an important role as a physiological regulator of adipocyte differentiation and metabolism."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci18698"xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Kahn C.R."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Stoffel M."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Wolfrum C."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Kuwajima S."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Norris A.W."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/author | "Shih D.Q."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/pages | "345-356"xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/title | "Role of Foxa-2 in adipocyte metabolism and differentiation."xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/12865419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12865419 |
| http://purl.uniprot.org/citations/12865419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12865419 |
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