| http://purl.uniprot.org/citations/12867159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12867159 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the Man-6-P-independent lysosomal sorting of prosaposin, a precursor of four saposins (A, B, C, and D) is not understood, a protein/lipid interaction is considered. Immunocytochemical analysis revealed that each single saposin linked to the C-terminus of prosaposin and to secretory albumin, drives the chimeric protein to lysosomes in COS-7 cells. Quantitative image analysis demonstrated that saposins are targeted with different efficiency (P<0.05) and in a less smooth manner than the precursor. Despite a very close homology, the charge distribution at the surface of 3D comparative models between saposins appeared different. Western blotting monitored prosaposin in cells also as a di- or trimeric form, whereas the chimeric saposins as monomeric. This implies that each amphipathic saposin-like motif may be a part of the overall structural requirements for binding of the precursor to the membrane lipids of transport vesicle. The crystal structure of saposin B demonstrating two dimeric units for lipid binding supports current findings."xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1065-6995(03)00124-0"xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/author | "Ham D."xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/pages | "675-687"xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/title | "Structural requirements for lysosomal targeting of the prosaposin precursor protein."xsd:string |
| http://purl.uniprot.org/citations/12867159 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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