| http://purl.uniprot.org/citations/12869379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12869379 | http://www.w3.org/2000/01/rdf-schema#comment | "In subjects heterozygous for Thr164Ile beta2-adrenoceptor (beta2AR) polymorphism, cardiac responses to beta2AR agonist stimulation are blunted. In this study, we investigated agonist-induced desensitization of Thr164Ile beta2ARs. For this purpose, we assessed in six subjects with heterozygous Thr164Ile beta2ARs and in 10 subjects with homozygous wild-type (WT) beta2ARs the effects of 2-wk oral treatment with 3 x 5 mg/day terbutaline on terbutaline infusion-induced increases in heart rate (HR) and contractility [measured as shortening of HR-corrected duration of electromechanical systole (QS2c)]. Compared with WT beta2AR subjects, Thr164Ile subjects exhibited a blunted terbutaline-induced maximum increase in HR (WT 32 +/-4 beats/min, Thr164Ile 19 +/-3 beats/min, P < 0.05) and contractility (WT -54 +/- 2 ms, Thr164Ile -37 +/-6 ms, P < 0.05). Two-week oral terbutaline treatment desensitized cardiac beta2AR responses to terbutaline infusion (increase in HR: WT 10 +/-2 beats/min, Thr164Ile 8 +/- 4 beats/min; increase in contractility: WT -22 +/-5 ms Thr164Ile: -17 +/-6 ms); however, the extent of desensitization was larger in WT than Thr164Ile beta2AR subjects. Thus, after 2-wk oral terbutaline treatment cardiac, beta2AR responses did not differ anymore between WT and Thr164Ile beta2AR subjects. We conclude that agonist-induced desensitization of cardiac beta2ARs is more pronounced in WT than Thr164Ile subjects. Thus cardiac Thr164Ile subjects appear to be somewhat protected against agonist-induced desensitization."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00324.2003"xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Heusch G."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Ulrich A."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Philipp T."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Radke J."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Brodde O.E."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Bruck H."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/author | "Leineweber K."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/pages | "H2034-8"xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/title | "Thr164Ile polymorphism of the human beta2-adrenoceptor exhibits blunted desensitization of cardiac functional responses in vivo."xsd:string |
| http://purl.uniprot.org/citations/12869379 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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