| http://purl.uniprot.org/citations/12870022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12870022 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundTo analyze the genetic polymorphism of HLA-Cw locus in Chinese Yi ethnic group by DNA typing for further study on its association with HIV infection and progression to AIDS.MethodsA rapid genotyping method for HLA-Cw by PCR-SSP was set up. It combined twenty-six specific primers and one pair of internal control primer to form twenty-four one-step reactions for each sample. Totally 102 unrelated healthy Chinese Yi ethnic individuals were typed.ResultsTwelve HLA-Cw alleles were detected in Chinese Yi ethnic group with HLA-Cw*01, Cw*07 and Cw*08 as the most common genes, which accounted for a frequency of 0.333 3, 0.250 0 and 0.176 5 respectively; four kinds of non-serologically defined HLA-Cw genes i.e. Cw*12, Cw*1301, Cw*14 and Cw*15 were found in this population. Hardy-Weinburg test showed that the genotype distribution observed was correspondent with the expected (chi2=65.983 1, df=66, P>0.05).ConclusionsThis study provides the data of HLA-Cw gene frequency in Chinese Yi ethnic group, which may contribute to research on anthropology, disease association and vaccine application. The result also confirmed that PCR-SSP was a reliable and fast method for HLA-Cw genotyping."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Chen J.P."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Li C.H."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Lu X.Z."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Zhu J.H."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Qin G.M."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Shao Y.M."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Ruan Y.H."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/author | "Hong K.X."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/name | "Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/pages | "62-65"xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/title | "[Genotyping of HLA-Cw locus in Chinese Yi ethnic group by PCR-SSP]."xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12870022 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12870022 |
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