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http://purl.uniprot.org/citations/12873589http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12873589http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of this study was to assess the influence of host genetic factors on response to combination therapy for chronic hepatitis C infection.

Methods

Patients with biopsy-proved chronic hepatitis C infection were treated with interferon alone (n = 143) or combined therapy of interferon + ribavarin (n = 105; 46 treatment naïve, 59 relapsers). Human leukocyte antigen (HLA) class I was determined by microlymphocytotoxicity and class II by polymerase chain reaction-single specific oligonucleotide. The two biallelic tumor necrosis factor-alpha promoter polymorphisms were studied by a polymerase chain reaction-amplification refractory mutation system. Other variables measured were viral genotype, hepatitis C virus RNA load, liver function tests, and ferritin concentration.

Results

Univariate analysis indicated that patients bearing HLA B44+, DRB1*03, infected by genotype non-1, with higher concentrations of transaminases and shorter duration of infection showed a higher sustained response (SR) rate than those on combination therapy. HLA class II and TNF-alpha promoter polymorphisms were not related to SR. In multivariate analysis, non-1 genotype (OR 2.42, 95% CI 1.12-5.55, p = 0.026) and HLA B44+ (OR 4.84, 95% CI 1.3-17.8, p = 0.017) were the independent variables associated with SR. However, HLA B44+ was not associated with SR in patients treated with interferon alone.

Conclusions

HLA class I B44 is related to a higher rate of SR in combination therapy but not in interferon monotherapy, whereas HLA class II, tumor necrosis factor-alpha -238A or -308A seem not to influence response to the antiviral therapy. These findings may be of value in therapy selection for hepatitis C-infected patients."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.org/dc/terms/identifier"doi:10.1111/j.1572-0241.2003.07537.x"xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Torres B."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Gonzalez-Escribano M.F."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Nunez-Roldan A."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Aguilar-Reina J."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Barroso N."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Montes-Cano M.A."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Romero-Gomez M."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/author"Sanchez-Munoz D."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/name"Am J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/pages"1621-1626"xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/title"HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis C."xsd:string
http://purl.uniprot.org/citations/12873589http://purl.uniprot.org/core/volume"98"xsd:string
http://purl.uniprot.org/citations/12873589http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12873589
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