| http://purl.uniprot.org/citations/12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12874215 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute graft-vs-host disease (GVHD) is influenced by pathways that can enhance or reduce lethality by providing positive or negative signals to donor T cells. To date, the only reported pathway to inhibit GVHD is the CTLA-4:B7 pathway. Because absence of the programmed death-1 (PD-1) pathway has been implicated in a predisposition to autoimmunity and hence a lack of negative signals, the effect of PD-1 pathway blockade on GVHD was explored using several distinct approaches. In each, GVHD lethality was markedly accelerated. Coblockade of CTLA-4 and PD-1 was additive in augmenting GVHD, indicating that these pathways are not fully redundant. Although neither perforin nor Fas ligand expression was required for GVHD enhancement, donor IFN-gamma production was required for optimal GVHD acceleration in the absence of PD-1 ligation. These data indicate that PD-1 ligation down-regulates GVHD through modulation of IFN-gamma production and suggest a novel therapeutic target for inhibiting GVHD lethality."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.3.1272"xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Nishimura H."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Carter L."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Iwai Y."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Carreno B.M."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Panoskaltsis-Mortari A."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/author | "Taylor P.A."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/pages | "1272-1277"xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/title | "Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/12874215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12874215 |
| http://purl.uniprot.org/citations/12874215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12874215 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874215 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874215 |
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| http://purl.uniprot.org/uniprot/#_A1Y9B0-mappedCitation-12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874215 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874215 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-12874215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874215 |