| http://purl.uniprot.org/citations/12874265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12874265 | http://www.w3.org/2000/01/rdf-schema#comment | "The malignant Hodgkin and Reed-Sternberg cells of Hodgkin's lymphoma (HL) and HL-derived B cell lines were previously shown to be resistant to different apoptotic stimuli. We show here that cytochrome c fails to stimulate caspases-9 and -3 activation in cytosolic extracts of HL-derived B cells, which is due to high level expression of X-linked inhibitor of apoptosis (XIAP). Coimmunoprecipitation studies revealed that XIAP, apoptosis protease-activating factor-1, and caspase-3 are complexed in HL-derived B cell lysates. Even after stimulation with exogenous cytochrome c and dATP, XIAP impairs the proteolytic processing and activation of caspase-3. In cytosolic extracts, inhibition of XIAP by the second mitochondria-derived activator of caspases (Smac)/DIABLO, or immunodepletion of XIAP restores cytochrome c-triggered processing and activation of caspase-3. Smac or a Smac-derived agonistic peptide also sensitized intact HL-derived B cells for the apoptotic action of staurosporine. Finally, Hodgkin and Reed-Sternberg cells of primary tumor HL tissues also constitutively and abundantly express XIAP. The results of this paper suggest that high level XIAP expression is a hallmark of HL, which may play a crucial role in resistance to apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021279"xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Shin H."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Salvesen G.S."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Kashkar H."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Kronke M."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Jurgensmeier J.M."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Haefs C."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/author | "Hamilton-Dutoit S.J."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/pages | "341-347"xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/title | "XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells."xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/12874265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12874265 |
| http://purl.uniprot.org/citations/12874265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12874265 |
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| http://purl.uniprot.org/uniprot/#_P98170-mappedCitation-12874265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874265 |
| http://purl.uniprot.org/uniprot/#_Q9NR28-mappedCitation-12874265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874265 |
| http://purl.uniprot.org/uniprot/P42574 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12874265 |
| http://purl.uniprot.org/uniprot/P98170 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12874265 |
| http://purl.uniprot.org/uniprot/Q9NR28 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12874265 |