| http://purl.uniprot.org/citations/12874352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12874352 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that numerous polymorphonuclear leukocyte (PMN) granule components efficiently kill Borrelia burgdorferi, the agent of Lyme disease. In addition, motile, granule-poor cytoplasts (U-Cyt) from human blood PMN can exert anti-Borrelia activity against opsonized B. burgdorferi independently of oxidative mechanisms. Here we show that lysates of U-Cyt also possess anti-Borrelia activity, a portion of which comes from the abundant cytosolic protein calprotectin. The anti-Borrelia activity of U-Cyt lysates and recombinant calprotectin was partially or completely reversed by specific antibody to calprotectin and by Zn(2+), a cation essential for the growth of B. burgdorferi and known to inhibit the antimicrobial activity of calprotectin. Quantitative microscopic and regrowth assays revealed that calprotectin acted in a bacteriostatic fashion against B. burgdorferi. We conclude that calprotectin, a potent bacteriostatic agent from a cell primarily recognized for its oxidative and granular antibacterial mechanisms, may play a modulatory role in infection by the Lyme spirochete, particularly at sites of acute inflammation."xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.71.8.4711-4716.2003"xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/author | "Malawista S.E."xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/author | "Montgomery R.R."xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/author | "Lusitani D."xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/pages | "4711-4716"xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/title | "Calprotectin, an abundant cytosolic protein from human polymorphonuclear leukocytes, inhibits the growth of Borrelia burgdorferi."xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/12874352 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12874352 |
| http://purl.uniprot.org/citations/12874352 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12874352 |
| http://purl.uniprot.org/uniprot/P06702#attribution-2ADE0FD941E117B57B5A59D06359CECB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12874352 |
| http://purl.uniprot.org/uniprot/#_B2R4M6-mappedCitation-12874352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874352 |
| http://purl.uniprot.org/uniprot/#_P06702-mappedCitation-12874352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12874352 |
| http://purl.uniprot.org/uniprot/B2R4M6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12874352 |
| http://purl.uniprot.org/uniprot/P06702 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12874352 |