| http://purl.uniprot.org/citations/12875835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12875835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12875835 | http://www.w3.org/2000/01/rdf-schema#comment | "The spliceosomal cyclophilin H is a specific component of the human U4/U6 small nuclear ribonucleoprotein particle, interacting with homologous sequences in the proteins U4/U6-60K and hPrp18 during pre-mRNA splicing. We determined the crystal structure of the complex comprising cyclophilin H and the cognate domain of U4/U6-60K. The 31 amino acid fragment of U4/U6-60K is bound to a region remote from the cyclophilin active site. Residues Ile118-Phe121 of U4/U6-60K expand the central beta-sheet of cyclophilin H and the side-chain of Phe121 inserts into a hydrophobic cavity. Concomitantly, in the crystal the cyclophilin H active site is occupied by the N terminus of a neighboring cyclophilin H molecule in a substrate-like manner, indicating the capacity of joint binding to a substrate and to U4/U6-60K. Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation. The complex defines a novel protein-protein interaction mode for a cyclophilin, allowing cyclophilin H to mediate interactions between different proteins inside the spliceosome or to initiate from its binding platforms isomerization or chaperoning activities."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2836(03)00684-3"xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2836(03)00684-3"xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Ficner R."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Ficner R."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Fasshauer D."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Fasshauer D."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Reidt U."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/author | "Reidt U."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/pages | "45-56"xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/pages | "45-56"xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/title | "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide."xsd:string |
| http://purl.uniprot.org/citations/12875835 | http://purl.uniprot.org/core/title | "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide."xsd:string |