| http://purl.uniprot.org/citations/12875885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12875885 | http://www.w3.org/2000/01/rdf-schema#comment | "The compounds 1-isopropylamino-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalate (5) and 1-tert-butylamino-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalate (6) were synthesized from thymol (1), a naturally occurring agent in Thymus vulgaris L. Pharmacological evaluation of 5 and 6 were carried out using mouse ECG and isolated rat uterus models. Pretreatment of 5 (100 microg/kg, i.v.) and 6 (50 microg/kg, i.v.) antagonized isoprenaline (2 microg/kg, i.v.) induced tachycardia, similar to that of atenolol (CAS 29122-68-7, 20 microg/kg, i.v.) pretreatment in mouse ECG experiments as measured by R-R interval. Pretreatment of 5 and 6 blocked isoprenaline and adrenaline induced relaxation of isolated rat uterus (unprimed). Also the compounds 5 and 6 were subjected to in vitro beta1- and beta2-adrenergic receptor binding assay using turkey erythrocyte membrane (beta1) and lung homogenate of rats (beta2). Both 5 and 6 showed beta-adrenergic receptor affinity comparable with that of propranolol (propranolol hydrochloride, CAS 318-98-9) with out selectivity to any one beta-adrenergic receptor. These results suggest that both the compounds possess non-selective beta-adrenergic blocking activity, with the tert-butyl derivative 6 being more active than the isopropyl derivative 5."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-827x(03)00083-1"xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Coumar M.S."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Bruni G."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Bodhankar S.L."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Collavoli E."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Jindal D.P."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Mahadik K.R."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Massarelli P."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Nandakumar K."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/author | "Purohit P.G."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/name | "Farmaco"xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/pages | "557-562"xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/title | "Synthesis, beta-adrenergic blocking activity and beta-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalates."xsd:string |
| http://purl.uniprot.org/citations/12875885 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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