| http://purl.uniprot.org/citations/12880539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12880539 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesSeveral factors, including abdominal obesity, insulin resistance, diabetes mellitus and low levels of high-density lipoprotein cholesterol have been implicated in the high prevalence and early onset of coronary heart disease in Asian Indians. However, there are no reports regarding the role of apolipoprotein E (apo E) gene polymorphisms in premature myocardial infarction (MI) in this population. This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels.Design and methodsApo E gene polymorphisms were analysed in 35 patients with MI aged <40 years and in 45 age- and sex-matched controls using polymerase chain reaction-restriction fragment length polymorphism. Levels of serum lipids were measured in addition to the evaluation of conventional risk factors.ResultsHigher frequencies of the apo E4 allele (P<0.0001) and of genotypes E3/E4 (P<0.005) and E4/E4 (P<0.005) were recorded in the premature MI group compared with the controls. Multivariate regression analysis revealed that, after adjusting for other covariates, individuals with the E4 allele were at ~46 times higher odds to develop premature MI compared with individuals without the E4 allele [adjusted odds ratio, OR (95% confidence interval, CI): 45.7 (4.9-421.3)]. Among conventional risk factors, higher risk was observed in those having dyslipidaemia [OR (95% CI): 8.7 (0.9-86.6)] and those with a high waist : hip ratio [OR (95% CI): 5.6 (1.4-21.2)].ConclusionBased on the robust association, the apo E4 allele should be considered as an independent risk factor for premature MI in Asian Indians."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.org/dc/terms/identifier | "doi:10.1258/000456303766477020"xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Kumar P."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Misra A."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Dwivedi M."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Luthra K."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Pandey R.M."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/author | "Behl V.K."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/name | "Ann Clin Biochem"xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/pages | "382-387"xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/title | "Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India."xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/12880539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12880539 |
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| http://purl.uniprot.org/uniprot/#_A0A346DBY2-mappedCitation-12880539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12880539 |
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