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| http://purl.uniprot.org/citations/12882324 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, the forkhead protein DAF-16 transduces insulin-like signals that regulate larval development and adult lifespan. To identify DAF-16-dependent transcriptional alterations that occur in a long-lived C. elegans strain, we used cDNA microarrays and genomic analysis to identify putative direct and indirect DAF-16 transcriptional target genes. Our analysis suggests that DAF-16 action regulates a wide range of physiological responses by altering the expression of genes involved in metabolism, energy generation and cellular stress responses. Furthermore, we observed a large overlap between DAF-16-dependent transcription and genes normally expressed in the long-lived dauer larval stage. Finally, we examined the in vivo role of 35 of these target genes by RNA-mediated interference and identified one gene encoding a putative protease that is necessary for the daf-2 Age phenotype."xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1474-9728.2003.00043.x"xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/author | "Bubb K."xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/author | "Thomas J.H."xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/author | "McElwee J."xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/pages | "111-121"xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/title | "Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16."xsd:string |
| http://purl.uniprot.org/citations/12882324 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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