| http://purl.uniprot.org/citations/12883492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12883492 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular retinol-binding protein-1 (CRBP-1) plays a key role in the esterification and intercellular transfer of retinol. By in situ hybridization, immunohistochemistry, and confocal laser scanning microscopy (CLSM), we show that, in normal liver, CRBP-1 is strongly expressed in the cytoplasm of hepatic stellate cells (HSCs) and myofibroblasts (MFs) with only low CRBP-1 levels in hepatocytes. By contrast, in 196 hepatocellular carcinoma (HCC) specimens CRBP-1 expression in MFs was down-regulated in 83%. Patients with high CRBP-1 expression in MFs had a significantly higher 2-year survival as compared with patients with low CRBP-1 expression (52% vs. 29%, respectively; P =.034). An aberrant nuclear CRBP-1 accumulation resulting from cytoplasmic invagination was found in 29% of HCCs. Nuclear CRBP-1 staining correlated positively with a favorable tumor stage (Okuda stage I; P =.01) and negatively with the Ki-67(+) proliferation fraction (PF). A Ki-67(+) PF of > or =10% was associated with a lower 2-year survival probability as compared with patients with a Ki-67(+) PF of <10% (12% vs. 40%, respectively; P =.015). Prognosis did not correlate with the nuclear beta-catenin expression. There was, however, a close correlation between nuclear CRBP-1 inclusions and nuclear beta-catenin staining in HCCs (P =.008), suggesting a cross talk between CRBP-1 and the Wnt/wingless signal transduction pathway. In conclusion, our findings demonstrate that CRBP-1 detection may be useful for the discrimination between nonneoplastic and neoplastic liver cells and suggest that modulation of CRBP-1 expression in HCCs contributes to tumor growth and progression via retinoid-mediated signaling and disruption of cellular vitamin A homeostasis."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.org/dc/terms/identifier | "doi:10.1053/jhep.2003.50321"xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Blum H.E."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Koelble K."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Nitschke R."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Gabbiani G."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Schmitt-Graff A."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Bochaton-Piallat M.L."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Allgaier H.P."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Ertelt V."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/author | "Olschewski M."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/pages | "470-480"xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/title | "Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival."xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/12883492 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12883492 |
| http://purl.uniprot.org/citations/12883492 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12883492 |
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| http://purl.uniprot.org/uniprot/#_P09455-mappedCitation-12883492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12883492 |
| http://purl.uniprot.org/uniprot/A0A0A0MQT0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12883492 |
| http://purl.uniprot.org/uniprot/P09455 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12883492 |