| http://purl.uniprot.org/citations/12884309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12884309 | http://www.w3.org/2000/01/rdf-schema#comment | "Major histocompatibility complex (MHC) class II molecules play an essential role for the cellular immune response by presenting peptide antigens to CD4(+) T cells. MHC class II molecules and genes show a highly complex expression pattern, which is orchestrated through a master regulatory factor, called CIITA (class II transactivator). CIITA controls MHC class II expression not only qualitatively, but also quantitatively, and has therefore a direct influence on the CD4 T cell-dependent immune response. CIITA is itself tightly regulated not only on the transcriptional level, but as we show here also on the protein level. CIITA is subjected to a very rapid protein turnover and shows a half-life of about 30 min. Inhibition of degradation by proteasome inhibitors and the identification of ubiquitylated CIITA intermediates indicate that the degradation of CIITA is mediated by the ubiquitin-proteasome system. We identified two regions mediating degradation within the N-terminal domain of CIITA. N-terminal fusions or deletions stabilized CIITA, indicating that the N termini contribute to degradation. Several non-functional CIITA mutants are partially stabilized, but we provide evidence that transcriptional activity of CIITA is not directly linked to degradation."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200323490"xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Hake S.B."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Bontron S."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Lisowska-Grospierre B."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Steimle V."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Camacho Carvajal M.M."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/author | "Schnappauf F."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/pages | "2337-2347"xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/title | "N-terminal destruction signals lead to rapid degradation of the major histocompatibility complex class II transactivator CIITA."xsd:string |
| http://purl.uniprot.org/citations/12884309 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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