| http://purl.uniprot.org/citations/12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/12884866 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-kappaB regulates the expression of various genes involved in cell growth and differentiation, immune response and inhibition of apoptosis. Recently, some death effector domain (DED)-containing proteins, such as FADD and c-FLIP were reported to activate NF-kappaB. We previously reported that the prodomain-only isoforms of caspase-8 and -10 (PDCasp8/10), containing two DED motifs, could inhibit Fas-mediated apoptosis. Here, we demonstrate that these isoforms also activate NF-kappaB, implying this to be one of the mechanisms by which these polypeptides inhibit apoptosis. The GST pull-down assay revealed that, among upstream kinases that activate NF-kappaB, only NIK and RIP, but not RICK or IKKalpha/beta, could directly bind to PDCasp8/10. In addition, both modules ofDED in PDCasp8/10 were required for these interactions as well as NF-kappaB activation. Experiments using a kinase-dead mutant of IKKalpha and an RIP mutant lacking a kinase domain, both of which function as dominant-negative mutants for their wild-type counterparts, blocked PDCasp8/10-mediated NF-kappaB activation. Using small interfering RNA technology, we further demonstrate that the down-regulation of IKKalpha but not IKKbeta significantly inhibits PDCasp8-mediated NF-kappaB activation. Taken together, these results suggest that caspase-8 and -10 have roles in a non- or anti-apoptotic signaling pathway leading to NF-kappaB activation through RIP, NIK and IKKalpha."xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200324013"xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/author | "Miyashita T."xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/author | "Shikama Y."xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/pages | "1998-2006"xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/title | "Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases."xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/12884866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12884866 |
| http://purl.uniprot.org/citations/12884866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12884866 |
| http://purl.uniprot.org/citations/12884866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12884866 |
| http://purl.uniprot.org/citations/12884866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12884866 |
| http://purl.uniprot.org/enzyme/3.4.22.63 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/Q14790#attribution-20567181AE5AF5B918255058FC7EBB2A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/Q92851#attribution-20567181AE5AF5B918255058FC7EBB2A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_Q14258-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_P39429-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_Q13158-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_Q14790-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_Q13546-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |
| http://purl.uniprot.org/uniprot/#_Q3U8L1-mappedCitation-12884866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12884866 |