| http://purl.uniprot.org/citations/12884965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12884965 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to test the role of mu and kappa opioid receptors (Mu opioid receptor (MOR) and Kappa opioid receptor (KOR)) in hippocampal-dependent spatial learning, we analyzed genetically engineered null mutant mice missing the functional MOR or KOR gene. Compared to wild-type mice, the homozygous MOR null mutants exhibited an impairment in the ultimate level of spatial learning as shown in two distinct tasks, the 8-arm radial-maze and the Morris water-maze. Control behaviors were normal. The learning impairment could be associated with the impairment we found in the maintenance of long-term potentiation in mossy fibers in CA3. In comparison, there was no impairment in spatial learning in our KOR mutants or in mossy fibers (mf) in CA3 region long-term potentiation (LTP). Our work suggests that the MOR may play a positive role in learning and memory by increasing LTP in CA3 neurons."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1601-183x.2003.00013.x"xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/author | "Kieffer B.L."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/author | "Simonin F."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/author | "Jamot L."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/author | "Matthes H.W."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/name | "Genes Brain Behav"xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/pages | "80-92"xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/title | "Differential involvement of the mu and kappa opioid receptors in spatial learning."xsd:string |
| http://purl.uniprot.org/citations/12884965 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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