| http://purl.uniprot.org/citations/12885770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12885770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12885770 | http://www.w3.org/2000/01/rdf-schema#comment | "The TRPS1 gene encodes a repressor of GATA-mediated transcription. Mutations in this gene cause the tricho-rhino-phalangeal syndromes, but the affected pathways are unknown. In a yeast two-hybrid screen with the C-terminal part of the murine Trps1 protein as bait, we obtained three yeast clones encoding two overlapping fragments of the 194 amino acids RING finger protein 4 (Rnf4). The overlap narrows down the Trps1-binding region within Rnf4 to amino acids 6-65. This region in Rnf4 is also known to interact with several proteins including steroid receptors. By using truncated Trps1 constructs, the Rnf4-binding region in Trps1 could be assigned to amino acids 985-1184 of 1281. This 200 amino acid region of Trps1 does not contain any predicted protein-protein interacting motif. Complex formation between the human proteins TRPS1 and RNF4 was verified by co-immunoprecipitation from transfected and native mammalian cells. Confocal laser-scanning microscopy revealed that the endogenous proteins are located in distinct structures of the nucleus. Using a luciferase reporter assay, we could demonstrate that the repressional function of TRPS1 is inhibited by RNF4. This finding suggests that RNF4 is a negative regulator of TRPS1 activity."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306259200"xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306259200"xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Moeroey T."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Moeroey T."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Horsthemke B."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Horsthemke B."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Luedecke H.J."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Luedecke H.J."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Kaiser F.J."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Kaiser F.J."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Chang G.T."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/author | "Chang G.T."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/pages | "38780-38785"xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/pages | "38780-38785"xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/title | "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/title | "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12885770 | http://purl.uniprot.org/core/volume | "278"xsd:string |