| http://purl.uniprot.org/citations/12887923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12887923 | http://www.w3.org/2000/01/rdf-schema#comment | "Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma, PAK-associated guanine nucleotide exchange factor (PIX alpha), Cdc42, and p21-activated kinase (PAK) 1. This pathway is utilized by chemoattractants to regulate directional sensing and directional migration of myeloid cells. Our results suggest that G beta gamma binds PAK1 and, via PAK-associated PIX alpha, activates Cdc42, which in turn activates PAK1. Thus, in this pathway, PAK1 is not only an effector for Cdc42, but it also functions as a scaffold protein required for Cdc42 activation. This G beta gamma-PAK1/PIX alpha/Cdc42 pathway is essential for the localization of F-actin formation to the leading edge, the exclusion of PTEN from the leading edge, directional sensing, and the persistent directional migration of chemotactic leukocytes. Although ligand-induced production of PIP(3) is not required for activation of this pathway, PIP(3) appears to localize the activation of Cdc42 by the pathway."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00559-2"xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Smrcka A.V."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Mo Z."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Huang C.K."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/author | "Hannigan M."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/pages | "215-227"xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/title | "Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42."xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/12887923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12887923 |
| http://purl.uniprot.org/citations/12887923 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12887923 |
| http://purl.uniprot.org/uniprot/#_A0A140VJJ8-mappedCitation-12887923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12887923 |
| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-12887923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12887923 |
| http://purl.uniprot.org/uniprot/#_A0A2L0WW42-mappedCitation-12887923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12887923 |