| http://purl.uniprot.org/citations/12888565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12888565 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood group P1/P2 is a glycolipid antigen system for which the genetic mechanism has not yet been clarified. We analyzed the potential of the cloned Gb3/CD77 synthase to synthesize P1 antigen, because Gb3/CD77 and P1 share a common structure, Galalpha1,4Galbeta1,4Glc (NAc)-. L cell transfectants with Gb3/CD77 synthase cDNA expressed marginal levels of P1 on the cell surface but contained high levels of P1 in the cytoplasm. P2-type erythrocytes, which were serotyped as P2, also contained definite P1 antigen inside cells, although the amounts were lower than those of P1 cells. Only p erythrocytes lacked P1 antigen corresponding with function-losing mutations in the Gb3/CD77 synthase gene. Synthesis of P1 antigen from paragloboside in vitro was demonstrated using membrane fraction of the transfectants and a fusion enzyme with protein A. These results strongly suggested that P1 synthase is identical to Gb3/CD77 synthase and appear to propose a clue for the solution of the long-pending P1/P2/p puzzle. The P1/P2 difference might result from the difference in P1 quantity based on either different enzyme activity or the presence/absence of other enzyme modulators. Because P2 erythrocytes showed lower levels of Gb3/CD77 synthase mRNA than P1, 5'-upstream promoter regions were analyzed, resulting in the identification of two P2-specific homozygous mutations. Differences in the transcriptional regulation in erythrocytes might be a major factor determining P1/P2."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m301609200"xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Furukawa K.'"xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Iwamura K."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Sojka B.N."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Uchikawa M."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Wiels J."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/author | "Shiku H."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/pages | "44429-44438"xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/title | "The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle."xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12888565 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12888565 |
| http://purl.uniprot.org/citations/12888565 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12888565 |
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| http://purl.uniprot.org/uniprot/#_A0A192ZI69-mappedCitation-12888565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12888565 |
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| http://purl.uniprot.org/uniprot/#_A0A345GNZ2-mappedCitation-12888565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12888565 |
| http://purl.uniprot.org/uniprot/#_B0L3P6-mappedCitation-12888565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12888565 |
| http://purl.uniprot.org/uniprot/#_B0L3P7-mappedCitation-12888565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12888565 |