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| http://purl.uniprot.org/citations/12891708 | http://www.w3.org/2000/01/rdf-schema#comment | "C1qRP/CD93 is a cell surface receptor predominantly expressed on monocytes, neutrophils, endothelial cells, and early stem cell precursors. In phagocytic cells, it has been characterized as contributing to the enhancement of FcR- and CR1-induced phagocytosis triggered by innate immune system defense collagens such as C1q and mannose binding lectin (MBL). Previously, we demonstrated a high level of glycosylation on C1qRP/CD93 that was predominantly O-linked. In this study, we investigate the role of glycosylation in C1qRP/CD93 stability first by inhibiting O-glycosylation by addition of benzyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside (BAG) to the human histiocytic cell line U937, and secondly, by expression of C1qRP/CD93 in the CHO-derived cell line ldlD which has a reversible defect in protein glycosylation. In both U937 cells and in ldlD cells transfected to express C1qRP/CD93, glycosylation deficiency caused cell surface expression levels of C1qRP/CD93 to decrease, concomitant with the detection of C1qRP/CD93 reactivity in the culture media. Metabolic labeling studies show that when glycosylation is absent, C1qRP/CD93 is synthesized and rapidly released into the culture supernatant or degraded. These studies demonstrate that O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 ."xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.10332"xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/author | "Tenner A.J."xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/pages | "512-522"xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/title | "Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation."xsd:string |
| http://purl.uniprot.org/citations/12891708 | http://purl.uniprot.org/core/volume | "196"xsd:string |
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