| http://purl.uniprot.org/citations/12893770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12893770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12893770 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common gamma chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), we analyzed effects of IL-21 compared with IL-15 on DC differentiation, maturation, and function. Here we show that DCs generated with granulocyte-macrophage colony-stimulating factor (GMCSF) in the presence of IL-21 (IL-21DCs) differentiated into phenotypically and functionally altered DCs characterized by reduced major histocompatibility complex class II (MHCII) expression, high antigen uptake, and low stimulatory capacity for T-cell activation in vitro. Additionally, IL-21DCs completely failed to induce antigen (Ag)-specific T-cell mediated contact hypersensitivity. Furthermore, IL-21 blocked lipopolysaccharide (LPS)-induced activation and maturation of DCs, which was not mediated by release of the anti-inflammatory cytokine IL-10. In contrast, when supplementing GMCSF with IL-15, DCs differentiated into mature antigen-presenting cells (APCs) with low antigen uptake and highly significant increased capacities to stimulate T cells in vitro and in vivo. Taken together, these results identify a dichotomous action of these structurally related cytokines on DCs, establishing IL-21 as inhibitory cytokine on DC activation and IL-15 as potent stimulator of DC function, making both cytokines interesting targets for therapeutic manipulation of DC-induced immune reactions."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-03-0669"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-03-0669"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Foster D.C."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Foster D.C."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Bulfone-Paus S."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Bulfone-Paus S."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Brandt K."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Brandt K."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Rueckert R."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/author | "Rueckert R."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/pages | "4090-4098"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/pages | "4090-4098"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/title | "Interleukin-21 inhibits dendritic cell activation and maturation."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/title | "Interleukin-21 inhibits dendritic cell activation and maturation."xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/12893770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12893770 |
| http://purl.uniprot.org/citations/12893770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12893770 |