| http://purl.uniprot.org/citations/12896973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12896973 | http://www.w3.org/2000/01/rdf-schema#comment | "Voltage-gated calcium channels couple changes in membrane potential to neuronal functions regulated by calcium, including neurotransmitter release. Here we report that presynaptic N-type calcium channels not only control neurotransmitter release but also regulate synaptic growth at Drosophila neuromuscular junctions. In a screen for behavioral mutants that disrupt synaptic transmission, an allele of the N-type calcium channel locus (Dmca1A) was identified that caused synaptic undergrowth. The underlying molecular defect was identified as a neutralization of a charged residue in the third S4 voltage sensor. RNA interference reduction of N-type calcium channel expression also reduced synaptic growth. Hypomorphic mutations in syntaxin-1A or n-synaptobrevin, which also disrupt neurotransmitter release, did not affect synapse proliferation at the neuromuscular junction, suggesting calcium entry through presynaptic N-type calcium channels, not neurotransmitter release per se, is important for synaptic growth. The reduced synapse proliferation in Dmca1A mutants is not due to increased synapse retraction but instead reflects a role for calcium influx in synaptic growth mechanisms. These results suggest N-type channels participate in synaptic growth through signaling pathways that are distinct from those that mediate neurotransmitter release. Linking presynaptic voltage-gated calcium entry to downstream calcium-sensitive synaptic growth regulators provides an efficient activity-dependent mechanism for modifying synaptic strength."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306417200"xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/author | "Guan Z."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/author | "Rieckhof G.E."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/author | "Yoshihara M."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/author | "Littleton J.T."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/pages | "41099-41108"xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/title | "Presynaptic N-type calcium channels regulate synaptic growth."xsd:string |
| http://purl.uniprot.org/citations/12896973 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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