| http://purl.uniprot.org/citations/12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12900457 | http://www.w3.org/2000/01/rdf-schema#comment | "In most animal species, germ cells require intimate contact with specialized somatic cells in the gonad for their proper development. We have analyzed the establishment of germ cell-soma interaction during embryonic gonad formation in Drosophila melanogaster, and find that somatic cells undergo dramatic changes in cell shape and individually ensheath germ cells as the gonad coalesces. Germ cell ensheathment is independent of other aspects of gonad formation, indicating that separate morphogenic processes are at work during gonadogenesis. The cell-cell adhesion molecule Drosophila E-cadherin is essential both for germ cell ensheathment and gonad compaction, and is upregulated in the somatic gonad at the time of gonad formation. Our data indicate that differential cell adhesion contributes to cell sorting and the formation of proper gonad architecture. In addition, we find that Fear of Intimacy, a novel transmembrane protein, is also required for both germ cell ensheathment and gonad compaction. E-cadherin expression in the gonad is dramatically decreased in fear of intimacy mutants, indicating that Fear of Intimacy may be a regulator of E-cadherin expression or function."xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00639"xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/author | "McCaffery J.M."xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/author | "Van Doren M."xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/author | "Jenkins A.B."xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/pages | "4417-4426"xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/title | "Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/12900457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12900457 |
| http://purl.uniprot.org/citations/12900457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12900457 |
| http://purl.uniprot.org/uniprot/Q24298#attribution-10626CECD6868D8CF8F75713BED74417 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/Q9VSL7#attribution-10626CECD6868D8CF8F75713BED74417 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6W2-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7S0-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_P09052-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_M9PES6-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_P25158-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_P25932-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_P28166-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_M9PBB5-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_P18824-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |
| http://purl.uniprot.org/uniprot/#_M9PGG4-mappedCitation-12900457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12900457 |