| http://purl.uniprot.org/citations/12900523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12900523 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular basis of thymocyte negative selection, which plays a critical role in establishing and maintaining immunological tolerance, is not yet resolved. In particular, the importance of the death receptor subgroup of the tumor necrosis factor (TNF)-family has been the subject of many investigations, with equivocal results. A recent report suggested that TRAIL was a critical factor in this process, a result that does not fit well with previous studies that excluded a role for the FADD-caspase 8 pathway, which is essential for TRAIL and Fas ligand (FasL) signaling, in negative selection. We have investigated intrathymic negative selection of TRAIL-deficient thymocytes, using four well-established models, including antibody-mediated TCR/CD3 ligation in vitro, stimulation with endogenous superantigen in vitro and in vivo, and treatment with exogenous superantigen in vitro. We were unable to demonstrate a role for TRAIL signaling in any of these models, suggesting that this pathway is not a critical factor for thymocyte negative selection."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20030634"xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Uldrich A.P."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Berzins S.P."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/author | "Cretney E."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/pages | "491-496"xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/title | "Normal thymocyte negative selection in TRAIL-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/12900523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12900523 |
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