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| http://purl.uniprot.org/citations/12902164 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells. Here, we discuss transcription factors that are involved in regulating the multistep molecular pathway of osteoblast differentiation. Runx2 and Osx, a newly identified zinc-finger-containing protein, are transcription factors that are expressed selectively and at high levels in osteoblasts. Null mutations of either leads to a complete absence of bone in mice. Runx2 plus its companion subunit Cbf beta are needed for an early step in this pathway, whereas Osx is required for a subsequent step, namely the differentiation of preosteoblasts into fully functioning osteoblasts. The finding that Osx-null cells acquire a chondrocyte phenotype implies that Osx is a negative regulator of Sox9 and of the chondrocyte phenotype. This leads to the hypothesis that Osx might have a role in the segregation of osteoblasts from osteochondroprogenitors. We also discuss recent progress in studies of other transcription factors that affect skeletal patterning and development."xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0168-9525(03)00176-8"xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/author | "Nakashima K."xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/author | "de Crombrugghe B."xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/name | "Trends Genet"xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/pages | "458-466"xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/title | "Transcriptional mechanisms in osteoblast differentiation and bone formation."xsd:string |
| http://purl.uniprot.org/citations/12902164 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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