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| http://purl.uniprot.org/citations/12904457 | http://www.w3.org/2000/01/rdf-schema#comment | "Timely deactivation of G-protein signaling is essential for the proper function of many cells, particularly neurons. Termination of the light response of retinal rods requires GTP hydrolysis by the G-protein transducin, which is catalyzed by a protein complex that includes regulator of G-protein signaling RGS9-1 and the G-protein beta subunit Gbeta5-L. Disruption of the Gbeta5 gene in mice (Gbeta5-/-) abolishes the expression of Gbeta5-L in the retina and also greatly reduces the expression level of RGS9-1. We examined transduction in dark- and light-adapted rods from wild-type and Gbeta5-/-mice. Responses of Gbeta5-/-rods were indistinguishable in all respects from those of RGS9-/-rods. Loss of Gbeta5-L (and RGS9-1) had no effect on the activation of the G-protein cascade, but profoundly slowed its deactivation and interfered with the speeding of incremental dim flashes during light adaptation. Both RGS9-/- and Gbeta5-/-responses were consistent with another factor weakly regulating GTP hydrolysis by transducin in a manner proportional to the inward current. Our results indicate that a complex containing RGS9-1-Gbeta5-L is essential for normal G-protein deactivation and rod function. In addition, our light adaptation studies support the notion than an additional weak GTPase-accelerating factor in rods is regulated by intracellular calcium and/or cGMP."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-18-06965.2003"xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/author | "Chen C.K."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/author | "Burns M.E."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/author | "Krispel C.M."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/pages | "6965-6971"xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/title | "Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice."xsd:string |
| http://purl.uniprot.org/citations/12904457 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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