http://purl.uniprot.org/citations/12906859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12906859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12906859 | http://www.w3.org/2000/01/rdf-schema#comment | "IRLB was originally identified as a partial cDNA clone, encoding a 191-aa protein binding the interferon-stimulated response element (ISRE) in the P2 promoter of human MYC. Here, we cloned the full-size IRLB using different bioinformatics tools and an RT-PCR approach. The full-size gene encompasses 131 kb within chromosome 15q22 and consists of 32 exons. IRLB is transcribed as a 6.6-kb mRNA encoding a protein of 1865 aa. IRLB is ubiquitously expressed and its expression is regulated in a growth- and cell cycle-dependent manner. In addition to the ISRE-binding domain IRLB contains a tripartite DENN domain, a nuclear localization signal, two PPRs, and a calmodulin-binding domain. The presence of DENN domains predicts possible interactions of IRLB with GTPases from the Rab family or regulation of growth-induced MAPKs. Strongly homologous proteins were identified in all available vertebrate genomes as well as in Caenorhabditis elegans and Drosophila melanogaster. In human and mouse a family of IRLB proteins exists, consisting of at least three members."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0888-7543(03)00103-4"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0888-7543(03)00103-4"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Baranova A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Baranova A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Corcoran M."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Corcoran M."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Kapanadze B."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Kapanadze B."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Kutsenko A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Kutsenko A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Semov A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Semov A."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Semova N."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/author | "Semova N."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/pages | "343-354"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/pages | "343-354"xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/title | "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges."xsd:string |
http://purl.uniprot.org/citations/12906859 | http://purl.uniprot.org/core/title | "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges."xsd:string |