| http://purl.uniprot.org/citations/12907426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12907426 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously shown that T lymphocytes and interferon-gamma are involved in hypercholesterolemia-induced leukocyte adhesion to vascular endothelium. This study assessed the contribution of interleukin 12 (IL-12) to these hypercholesterolemia-induced inflammatory responses. Intravital videomicroscopy was used to quantify leukocyte adhesion and emigration and oxidant stress (dihydrorhodamine oxidation) in unstimulated cremasteric venules (wall shear rate > or =500 s-1) of wild-type (WT) C57Bl/6, lymphocyte-deficient [recombinase-activating gene knockout (RAG1-/-)], and IL-12-deficient (p35-/- and p40-/-; p35 and p40 are the two subunits of active IL-12) mice on either a normal (ND) or high-cholesterol (HC) diet for 2 wk. RAG1-/--HC mice received splenocytes from WT-HC (WT --> RAG1-/-), p35-/--HC (p35-/---> RAG1-/-), or p40-/--HC (p40-/---> RAG1-/-) mice. Compared with WT-ND mice, WT-HC mice exhibited exaggerated leukocyte adherence and emigration as well as increased dihydrorhodamine oxidation. The enhanced leukocyte recruitment was absent in the RAG1-/--ND, p35-/--ND, and p40-/--ND groups. Hypercholesterolemia-induced leukocyte adherence and emigration were attenuated in RAG1-/--HC vs. WT-HC mice but were similar to ND mice. Furthermore, compared with WT-HC animals, p35-/--HC and p40-/--HC mice showed significantly lower leukocyte adhesion and tissue oxidant stress responses, but these values were comparable to ND mice. Leukocyte adherence and emigration in WT --> RAG1-/-mice were similar to responses of WT-HC mice. However, p35-/- --> RAG1-/-mice had lower levels of adherence and emigration vs. the WT --> RAG1-/- and WT-HC groups. Elevated levels of leukocyte adherence and emigration were restored by approximately 50% toward WT-HC levels in p40-/- --> RAG1-/-mice. These findings implicate IL-12 in the inflammatory responses observed in the venules of hypercholesterolemic mice."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00566.2003"xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/author | "Granger D.N."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/author | "Clanton E.C."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/author | "Stokes K.Y."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/author | "Gehrig J.L."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/pages | "H2623-9"xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/title | "Role of interleukin 12 in hypercholesterolemia-induced inflammation."xsd:string |
| http://purl.uniprot.org/citations/12907426 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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