| http://purl.uniprot.org/citations/12909344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12909344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12909344 | http://www.w3.org/2000/01/rdf-schema#comment | "The terminal enzyme of the mitochondrial respiratory chain, cytochrome c oxidase (COX), contains three mitochondrial and ten nuclear encoded subunits in mammals. Three of the nuclear subunits (VIa, VIIa, and VIII) have muscle and non-muscle-specific isoforms, subunit IV contains a lung-specific isoform, and subunit VIb contains a testes-specific isoform. For subunit VIII, the smallest nuclear encoded COX polypeptide, we have now found a third gene (COX 8-3), which has been identified in human, lemur, rat, and mouse, suggesting that it is present in a broad range of Eutherian mammals. Sequence similarity and gene structure support the homology of COX8-3 to the other subunit VIII isoforms, indicating that all three are the product of gene duplications. COX VIII-3 protein is mitochondrially-targeted, as shown by a fluorescent COX VIII3/DsRed fusion protein. Both the mitochondrial targeting and its sequence conservation suggest that COXVIII-3 functions as part of the COX holoenzyme and could have a tissue-specific role, as is the case for the other two isoforms. Questions remain about where COX8-3 is predominantly expressed. However, detection of full-length cDNAs, lower levels of sequence divergence at the first and second codon positions compared to the third, and a conserved gene structure indicate that COX VIII-3 is an expressed gene whose origin dates to at least 91 million years ago."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(03)00604-8"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(03)00604-8"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Huettemann M."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Huettemann M."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Grossman L.I."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Grossman L.I."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Schmidt T.R."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/author | "Schmidt T.R."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/pages | "95-102"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/pages | "95-102"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/title | "A third isoform of cytochrome c oxidase subunit VIII is present in mammals."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/title | "A third isoform of cytochrome c oxidase subunit VIII is present in mammals."xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/12909344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12909344 |
| http://purl.uniprot.org/citations/12909344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12909344 |
| http://purl.uniprot.org/citations/12909344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12909344 |
| http://purl.uniprot.org/citations/12909344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12909344 |