| http://purl.uniprot.org/citations/12909644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12909644 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to its recognition by alpha3beta1 and alpha4beta1 integrins, the N-terminal pentraxin module of thrombospondin-1 is a ligand for alpha6beta1 integrin. alpha6beta1 integrin mediates adhesion of human microvascular endothelial and HT-1080 fibrosarcoma cells to immobilized thrombospondin-1 and recombinant N-terminal regions of thrombospondin-1 and thrombospondin-2. alpha6beta1 also mediates chemotaxis of microvascular cells to thrombospondin-1 and thrombospondin-2. Using synthetic peptides, LALERKDHSG was identified as an alpha6beta1-binding sequence in thrombospondin-1. This peptide inhibited alpha6beta1-dependent cell adhesion to thrombospondin-1, thrombospondin-2, and the E8 fragment of murine laminin-1. The Glu residue in this peptide was required for activity, and the corresponding residue (Glu90) in the N-terminal module of thrombospondin-1 was required for its recognition by alpha6beta1, but not by alpha4beta1. alpha6beta1 was also expressed in human umbilical vein endothelial cells; but in these cells, only certain agonists could activate the integrin to recognize thrombospondins. Selective activation of alpha6beta1 integrin in microvascular endothelial cells by the anti-beta1 antibody TS2/16 therefore accounts for their adhesion responses to thrombospondins and explains the distinct functions of alpha4beta1 and alpha6beta1 integrins as thrombospondin receptors in microvascular and large vessel endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302014200"xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Krutzsch H.C."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Yurchenco P.D."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Roberts D.D."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Calzada M.J."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/author | "Sipes J.M."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/pages | "40679-40687"xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/title | "Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin."xsd:string |
| http://purl.uniprot.org/citations/12909644 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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