| http://purl.uniprot.org/citations/12910389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12910389 | http://www.w3.org/2000/01/rdf-schema#comment | "Hydrostatic pressure is one of the physical factors affecting cellular physiology. Hydrostatic pressure of a few hundred MPa decreases the viability of yeast cells, and pressure of a few tens MPa decreases the growth rate. To understand the effect of hydrostatic pressure, we employed yeast DNA microarrays and analyzed genome-wide gene-expression levels after the pressure treatment with 180 MPa (immediate) at 4 degrees C and recovery incubation for 1 h and 40 MPa (16 h) at 4 degrees C and recovery incubation for 1 h. The transcription of genes involved in energy metabolism, cell defense, and protein metabolism was significantly induced by the pressure treatment. Genome-wide expression profiles suggested that high pressure caused damage to cellular organelles, since the induced gene products were localized in the membrane structure and/or cellular organelles. Hierarchical clustering analysis suggested that the damage caused by the pressure was similar to that caused by detergents, oils, and freezing/thawing. We also estimated the contribution of induced genes to barotolerance using some strains that have the deletion in the corresponding genes."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00792-003-0322-y"xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/author | "Iwahashi H."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/author | "Komatsu Y."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/author | "Odani M."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/name | "Extremophiles"xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/pages | "291-298"xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/title | "Piezophysiology of genome wide gene expression levels in the yeast Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/12910389 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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