| http://purl.uniprot.org/citations/12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12911285 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the prevalence of autoimmune thyroid disease (AITD) in children and adolescents with type 1 diabetes mellitus (DM), and assess whether the development of AITD is correlated with specific DQ-A and DQ-B loci of the HLA class II antigens, we analyzed thyroid function using anti-thyroid antibodies and HLA-DQ-A and -DQ-B polymorphisms in 69 patients with type 1 DM, in 75 normal healthy controls, and in 21 patients with AITD but without type 1 DM. Eighteen patients (26%) in the diabetic patients had AITD. In the diabetic patients, DQA1*0301 and DQB1*0302 occurred more frequently than in controls [DQA1*0301: OR = 1.939, 95% CI = 1.210-3.109 (P = 0.008, P(c) (corrected P) < 0.05); DQB1*0302: OR = 2.558, 95% CI = 1.354-4.832 (P = 0.005, P(c), > 0.05)]. Compared with controls, non-diabetic subjects with AITD showed higher frequency of DQA1*0301 (P(c), < 0.05) and DQB1*0601 (P(c) > 0.05), but these alleles were not contributing factors in the development of AITD in diabetic patients. In diabetic patients, DQB1*0201, known as susceptible allele of type 1 DM was not a contributing factor in the development of AITD in diabetic patients. Unlike DQB1*0201, DQB1*0401 was more frequently found in diabetic patients with AITD than in controls [OR = 4.053, 95% CI = 1.607-10.221 (P = 0.0017, P(c) < 0.05)] or than in non-diabetic AITD patients [OR = 15.769, 95% CI = 1.905-130.530(P = 0.002, P(c) < 0.05)]. In non-diabetic subjects, DQB1*0401 did not provide susceptibility for AITD. Our results suggest that HLA DQB1*0401 is a predisposing genetic marker for the development of AITD in patients with type 1 DM in Korea."xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.org/dc/terms/identifier | "doi:10.1080/0891693031000101279"xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/author | "Kim E.Y."xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/author | "Yang S.W."xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/author | "Shin C.H."xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/pages | "177-181"xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/title | "Polymorphisms of HLA class II predispose children and adolescents with type 1 diabetes mellitus to autoimmune thyroid disease."xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/12911285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12911285 |
| http://purl.uniprot.org/citations/12911285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE6-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCZ4-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCZ9-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD03-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD05-mappedCitation-12911285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12911285 |