| http://purl.uniprot.org/citations/12911596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12911596 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevated circulating plasminogen activator inhibitor-1 (PAI-1) may increase risk of cardiovascular disease (CVD). The 4G allele of the 4G/5G PAI-1 promoter polymorphism is associated with higher levels of PAI-1. We examined the association of PAI-1 4G/5G genotype and CVD events in the elderly participants of the Cardiovascular Health Study (CHS). We measured 4G/5G genotype in a nested case-control study within the CHS. Cases included incident angina, myocardial infarction (MI), and stroke. 4G/5G genotype was not found to be associated with markers of fibrinolysis or CVD risk in the selected elderly cohort. There were no differences in genotype frequencies by case-control status (5G/5G frequency 16-22%; chi2P= 0.07). The 5G allele was not associated with incident CVD events when individuals with at least one 5G allele were compared to 4G/4G homozygotes. The presence of at least one 4G allele was likewise not associated with incident CVD when those with 4G/4G and 4G/5G genotypes were compared to 5G/5G homozygotes. Our results suggest that the PAI-1 4G/5G promoter polymorphism is not associated CVD risk factors or incident CVD events in the elderly."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1538-7836.2003.00255.x"xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Arnold A.M."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Kuller L.H."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Sharrett A.R."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Tracy R.P."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Jenny N.S."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Crainich P."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/author | "Manolio T."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/name | "J Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/pages | "1799-1804"xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/title | "Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly."xsd:string |
| http://purl.uniprot.org/citations/12911596 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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