| http://purl.uniprot.org/citations/12925700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12925700 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated recruitment and clearance of neutrophils (PMN) is the hallmark of competent host defense and resolution of inflammation. We now report that IFN-gamma controls PMN infiltration and modulates IL-6 signaling through its soluble receptor (sIL-6R) to promote their apoptosis and clearance. Induction of peritoneal inflammation in IFN-gamma-deficient (IFN-gamma-/-) mice emphasized that the initial rate of PMN recruitment was impaired. This defect in PMN recruitment was also associated with the suppressed intraperitoneal expression of IL-1beta and IL-6. Reconstitution of IFN-gamma signaling restored the rate of PMN infiltration and IL-6 levels and was accompanied by normalization of PMN-activating CXC chemokine expression. To test whether local IL-6 signaling modulated PMN recruitment, inflammation was induced in IFN-gamma-/- and IL-6-/-mice and cytokine signaling adapted by intraperitoneal sIL-6R-IL-6 fusion protein (HYPER-IL-6) or IFN-gamma. Although HYPER-IL-6 attenuated PMN influx in IFN-gamma-/- mice, IFN-gamma had no effect on PMN infiltration in IL-6-/-mice. Examination of the leukocyte infiltrate from IFN-gamma-/-, IL-6-/-, and wild-type mice showed that apoptosis was aberrant in the absence of IFN-gamma and IL-6 as a result of impaired sIL-6R signaling. These data emphasize a pivotal role for IFN-gamma in regulating innate immunity through control of both the recruitment and clearance phases of PMN trafficking."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci17129"xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Jones S.A."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Robson R.L."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Hurst S.M."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Williams A.S."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Williams J.D."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Wilkinson T.S."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "McLoughlin R.M."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Topley N."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/author | "Witowski J."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/pages | "598-607"xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/title | "Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation."xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/12925700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12925700 |
| http://purl.uniprot.org/citations/12925700 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12925700 |
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| http://purl.uniprot.org/uniprot/P01580#attribution-70DB028C0E91DB8D4AF7213E109032EF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12925700 |
| http://purl.uniprot.org/uniprot/P10749#attribution-1E12B156A65912D1DA225D231C626D71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12925700 |
| http://purl.uniprot.org/uniprot/P08505#attribution-1E12B156A65912D1DA225D231C626D71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12925700 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-12925700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12925700 |