| http://purl.uniprot.org/citations/12925702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12925702 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-adrenergic receptors (betaARs) relax airway smooth muscle and bronchodilate, but chronic beta-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated betaAR genes (betaAR-/-) and transgenic mice overexpressing airway smooth muscle beta2AR (beta2AR-OE) representing two extremes: absence and persistent activity of airway betaAR. Unexpectedly, betaAR-/-mice, lacking these bronchodilating receptors, had markedly decreased bronchoconstrictive responses to methacholine and other Gq-coupled receptor agonists. In contrast, beta2AR-OE mice had enhanced constrictive responses. Contraction to permeabilization with beta-escin was unaltered by gene ablation or overexpression. Inositol phosphate accumulation by Gq-coupled M3-muscarinic, thromboxane-A2, and 5-HT2 receptors was desensitized in airway smooth muscle cells from betaAR-/-mice and sensitized in cells from beta2AR-OE mice. Thus, betaAR antithetically regulates constrictive signals, affecting bronchomotor tone/reactivity by additional means other than direct dilatation. Studies of signaling elements in these pathways revealed the nodal point of this cross talk as phospholipase C-beta1, whose expression was altered by betaAR in a direction and magnitude consistent with the physiologic and cellular responses. These results establish a mechanism of the beta-agonist paradox and identify a potential asthma modifier gene (phospholipase C-beta1), which may also be a therapeutic target in asthma when chronic beta-agonists are required."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci18193"xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/author | "Kobilka B.K."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/author | "Liggett S.B."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/author | "McGraw D.W."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/author | "Paul R.J."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/author | "Almoosa K.F."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/pages | "619-626"xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/title | "Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox."xsd:string |
| http://purl.uniprot.org/citations/12925702 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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