| http://purl.uniprot.org/citations/12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12928432 | http://www.w3.org/2000/01/rdf-schema#comment | "PLCgamma2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function. Here, we show that PLCgamma2 deficiency specifically blocks B cell maturation at the transitional type 2 (T2) to follicular (FO) B cell transition and the PLCgamma2 pathway regulates survival of B cells. BCR-induced apoptosis is dramatically enhanced in all subsets of splenic PLCgamma2-deficient B cells, especially in T2 and FO B cell subpopulations. We also find that all splenic PLCgamma2-deficient B cell subpopulations express abnormally low levels of Bcl-2 protein. In addition, PLCgamma2 deficiency disrupts BCR-mediated induction of A1 expression. Enforced expression of Bcl-2 prevents BCR-induced apoptosis in all splenic PLCgamma2-deficient B cell subpopulations and partially restores the numbers of PLCgamma2-deficient FO B cells. In contrast to Bcl-2, enforced expression of A1 preferentially prevents BCR-induced apoptosis in PLCgamma2-deficient FO B cells and partially restores the numbers of these B cells. Therefore, the PLCgamma2 pathway provides a survival signal via regulation of Bcl-2 in all splenic B cell subpopulations and via additional induction of A1 in mature FO B cells."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m307318200"xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Morris S.W."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Wen R."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Xue L."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/author | "Schuman J."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/pages | "43654-43662"xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/title | "Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells."xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12928432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12928432 |
| http://purl.uniprot.org/citations/12928432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12928432 |
| http://purl.uniprot.org/uniprot/Q07440#attribution-F1458B56813DC53CB64F5AC1470256A9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/Q8CIH5#attribution-A4658B6FCE4A0B98A041ABB2D562A9A5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_P10417-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_Q8BQK4-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_Q07440-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_Q8K164-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_Q4FK02-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |
| http://purl.uniprot.org/uniprot/#_Q8CIH5-mappedCitation-12928432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12928432 |