| http://purl.uniprot.org/citations/12930749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12930749 | http://www.w3.org/2000/01/rdf-schema#comment | "The first committed step in the purine de novo synthesis pathway is performed by amidophosphoribosyltransferase (EC 2.4.2.14) or Prat. Drosophila melanogaster Prat is an essential gene with a promoter that lacks a TATA-box and initiator element and has multiple transcription start sites with a predominant start site. To study the regulation of Prat expression in the adult eye, we used the Prat:bw reporter gene, in which the Prat coding region was replaced with the brown (bw) coding region. The pale-orange eye color of a single copy of Prat:bw prompted us to use a multicopy array of Prat:bw that was derived using P transposase mutagenesis and produces a darker-orange eye color in a bw(D); st genetic background. We used a 13-copy array of Prat:bw as a tool to recover dominant EMS-induced mutations that affect the expression of the transgene. After screening 21,000 F(1)s for deviation from the orange eye color, we isolated 23 dominant modifiers: 21 suppressors (1 Y-linked, 5 X-linked, 4 2-linked, and 11 3-linked) and 2 enhancers (1 2-linked and 1 3-linked). Quantification of their effect on endogenous Prat gene expression, using RT-PCR in young adult fly heads, identifies a subset of modifiers that are candidates for genes involved in regulating Prat expression."xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/164.4.1419"xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/author | "Malmanche N."xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/author | "Clark D.V."xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/pages | "1419-1433"xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/title | "Identification of trans-dominant modifiers of Prat expression in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/12930749 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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