| http://purl.uniprot.org/citations/12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12935821 | http://www.w3.org/2000/01/rdf-schema#comment | "The two discoidin domain receptors, DDR1 and DDR2, are tyrosine kinases that are activated by collagen and are essential regulators of cell-matrix communication. However, the target genes downstream of activated DDRs and their physiological significance are largely unknown. Here, we describe a novel method to dissect signaling pathways induced by extracellular matrix (ECM) receptors. Using the doxycycline-inducible repression system (tet-off), we generated human fibrosarcoma and mouse fibroblast cell lines over-expressing DDR1 or DDR2. These cell lines were employed for gene expression analysis using microarrays specific for human and mouse genes coding for ECM proteins or ECM-interacting factors. We found that approximately 10% of the genes studied were up- or down-regulated more than twofold in response to signals generated by over-expressing DDRs. A common event downstream of DDR1 and DDR2 in human and mouse cells was the up-regulation of P-selectin glycoprotein ligand. Key target genes repressed upon DDR activation were agrin, syndecan-1 and alpha3 integrin. ECM-specific microarrays were found a valuable tool to dissect gene expression changes induced by collagen-receptor signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0945-053x(03)00053-2"xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/author | "Bosio A."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/author | "Vogel W.F."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/author | "Eck M."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/author | "Gerstmayer B."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/author | "Faraci E."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/pages | "373-381"xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/title | "An extracellular matrix-specific microarray allowed the identification of target genes downstream of discoidin domain receptors."xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12935821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12935821 |
| http://purl.uniprot.org/citations/12935821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12935821 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSX3-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_A0A024RCQ1-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7K3-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7L5-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7M1-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_B7Z3A2-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_Q08345-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_Q16832-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_Q5J7V3-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |
| http://purl.uniprot.org/uniprot/#_Q6MZT2-mappedCitation-12935821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935821 |