| http://purl.uniprot.org/citations/12935886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12935886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12935886 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report, we cloned a novel calmodulin-kinase (CaM-KIdelta) from HeLa cells and characterized its activation mechanism. CaM-KIdelta exhibits Ca(2+)/CaM-dependent activity that is enhanced (approximately 30-fold) in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha, consistent with detection of CaM-KIdelta-activating activity in HeLa cells. We also identified a novel CaM-KKbeta isoform (CaM-KKbeta-3) in HeLa cells whose activity was highly Ca(2+)/CaM-independent. Transiently expressed CaM-KIdelta exhibited enhanced protein kinase activity in HeLa cells without ionomycin stimulation. This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)00817-2"xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)00817-2"xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Inuzuka H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Inuzuka H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Hosoya H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Hosoya H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Tokumitsu H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Tokumitsu H."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Murata-Hori M."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/author | "Murata-Hori M."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/pages | "57-63"xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/pages | "57-63"xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/title | "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells."xsd:string |
| http://purl.uniprot.org/citations/12935886 | http://purl.uniprot.org/core/title | "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells."xsd:string |