| http://purl.uniprot.org/citations/12935897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12935897 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Cool protein family contain SH3, Dbl, and pleckstrin homology domains and are binding partners for the p21-activated kinase (PAK). Using the yeast two-hybrid screen, we identified Cbl-b as a Cool family binding partner. We co-immunoprecipitated endogenous Cool and Cbl-b from a variety of breast cancer cell lines. The Cool-Cbl-b interaction requires the SH3 domain of Cool and competes with the binding of PAK to Cool proteins. Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, thus providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(03)00853-6"xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Cerione R.A."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Feng Q."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Bagrodia S."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Flanders J.A."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Laux M.T."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/author | "Singavarapu A."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/pages | "119-123"xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/title | "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins."xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://purl.uniprot.org/core/volume | "550"xsd:string |
| http://purl.uniprot.org/citations/12935897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12935897 |
| http://purl.uniprot.org/citations/12935897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12935897 |
| http://purl.uniprot.org/uniprot/#_Q14155-mappedCitation-12935897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935897 |
| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-12935897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935897 |
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| http://purl.uniprot.org/uniprot/#_Q13191-mappedCitation-12935897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935897 |
| http://purl.uniprot.org/uniprot/#_Q8N4Q3-mappedCitation-12935897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12935897 |
| http://purl.uniprot.org/uniprot/B7Z3C7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12935897 |
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